Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell-Nanoparticle Interaction

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	Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell-Nanoparticle Interaction
	Zhang L; Feng Q; Wang JL; Zhang S; Ding BQ; Wei YJ(魏宇杰); Dong MD; Ryu JY; Yoon TY; Shi XH
刊名	ACS NANO
	2015-10
通讯作者邮箱	shixh@imech.ac.cn ; sunjs@nanoctr.cn ; xingyujiang@nanoctr.cn
卷号	9 期号:10 页码:9912-9921
关键词	nanostructures lipids microfluidics interfaces drug deliver
ISSN号	1936-0851
通讯作者	Jiang, XY (reprint author), Natl Ctr Nanosci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China.
产权排序	[Zhang, Lu; Feng, Qiang; Ding, Baoquan; Shi, Xinghua; Sun, Jiashu; Jiang, Xingyu] Natl Ctr Nanosci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China; [Zhang, Lu; Feng, Qiang; Ding, Baoquan; Shi, Xinghua; Sun, Jiashu; Jiang, Xingyu] Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China; [Wang, Jiuling; Wei, Yujie] Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China; [Zhang, Shuai; Dong, Mingdong] Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, DK-8000 Aarhus C, Denmark; [Ryu, Ji-Young; Yoon, Tae-Young] Korea Adv Inst Sci & Technol, Natl Creat Res Initiat Ctr Single Mol Syst Biol, Taejon 305701, South Korea; [Ryu, Ji-Young; Yoon, Tae-Young] Korea Adv Inst Sci & Technol, Dept Phys, Taejon 305701, South Korea
中文摘要	The functionalized lipid shell of hybrid nanoparticles plays an important role for improving their biocompatibility and in vivo stability. Yet few efforts have been made to critically examine the shell structure of nanoparticles and its effect on cell particle interaction. Here we develop a microfluidic chip allowing for the synthesis of structurally well-defined lipid-polymer nanoparticles of the same sizes, but covered with either lipid-monolayer-shell (MPs, monolayer nanoparticles) or lipid-bilayer-shell (BPs, bilayer nanoparticles). Atomic force microscope and atomistic simulations reveal that MPs have a lower flexibility than BPs, resulting in a more efficient cellular uptake and thus anticancer effect than BPs do. This flexibility-regulated cell particle interaction may have important implications for designing drug nanocarriers.
分类号	一类
类目[WOS]	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics ; Materials Science
关键词[WOS]	CORE-SHELL NANOPARTICLES ; DRUG-DELIVERY ; CANCER-THERAPY ; NANOMATERIALS ; ENTRY ; SIRNA
收录类别	SCI ; EI
原文出处	http://dx.doi.org/10.1021/acsnano.5b05792
语种	英语
WOS记录号	WOS:000363915300048
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/58388]
专题	力学研究所_非线性力学国家重点实验室
推荐引用方式 GB/T 7714	Zhang L,Feng Q,Wang JL,et al. Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell-Nanoparticle Interaction[J]. ACS NANO,2015,9(10):9912-9921.
APA	Zhang L.,Feng Q.,Wang JL.,Zhang S.,Ding BQ.,...&Wang JL.(2015).Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell-Nanoparticle Interaction.ACS NANO,9(10),9912-9921.
MLA	Zhang L,et al."Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell-Nanoparticle Interaction".ACS NANO 9.10(2015):9912-9921.