Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers

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	Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers
	Ren, Wenzhi ; Zeng, Leyong ; Shen, Zheyu ; Xiang, Lingchao ; Gong, An ; Zhang, Jichao（张继超） ; Mao, Chengwen ; Li, Aiguo（李爱国） ; Paunesku, Tatjana ; Woloschak, Gayle E. ; Hosmane, Narayan S. ; Wu, Aiguo
刊名	RSC ADVANCES
	2013
卷号	3 期号:43 页码:CONCATENATE(Sheet1!I116,-Sheet1!J116)
ISSN号	2046-2069
英文摘要	In order to overcome the multidrug resistance of breast cancer cells, doxorubicin was loaded onto TiO2 nanoparticles in which the electrostatic interactions hold the drug and the nanoparticles together. The anticancer activity of this nanocomposite was evaluated in multidrug resistant breast cancer cells. In nanocomposite treated MCF-7/ADM cells, drug accumulation increased with enhanced anticancer activity about 2.4 times compared to that of doxorubicin alone. The potential mechanism of enhanced drug accumulation is ascribed to the fact that the nanocomposite directly transports the drugs into cells via internalization, bypassing the P-glycoprotein mediated doxorubicin pumping system. Our results reinforce that the nanocomposite, as a pH controlled drug release system, could be used to overcome multidrug resistance of human breast cancer cells.
收录类别	SCI
语种	英语
WOS记录号	WOS:000325950600167
公开日期	2014-06-13
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/13613]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Ren, Wenzhi,Zeng, Leyong,Shen, Zheyu,et al. Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers[J]. RSC ADVANCES,2013,3(43):CONCATENATE(Sheet1!I116,-Sheet1!J116).
APA	Ren, Wenzhi.,Zeng, Leyong.,Shen, Zheyu.,Xiang, Lingchao.,Gong, An.,...&Wu, Aiguo.(2013).Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers.RSC ADVANCES,3(43),CONCATENATE(Sheet1!I116,-Sheet1!J116).
MLA	Ren, Wenzhi,et al."Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers".RSC ADVANCES 3.43(2013):CONCATENATE(Sheet1!I116,-Sheet1!J116).