Cytotoxic, cell apoptosis and DNA binding properties of some ternary Cu(II) complexes with a reduced Schiff base ligand and heterocyclic bases

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	Cytotoxic, cell apoptosis and DNA binding properties of some ternary Cu(II) complexes with a reduced Schiff base ligand and heterocyclic bases
	Jia L(贾磊)1,2; Cai, Hong-xin 1; Xu, Jun 1; Zhou, Heng 3; Wu, Wei-na 1; Li, Fei-fei 1; Wang, Yuan 1; Pei XW(裴小维)2 ; Wang, Qin 3
刊名	Inorganic Chemistry Communications
	2013
卷号	35 页码:16-18
关键词	Cell apoptosis Cytotoxicity DNA binding properties Reduce Schiff base Hoechst 33258 Ternary Cu(II) complexes
ISSN号	1387-7003
通讯作者	贾磊 ; Wang, Qin
英文摘要	Three mononuclear mixed ligand Cu(II) complexes of the type [Cu(L)(DTHA)]H₂O center dot CH₃OH, where H₂DTHA is 2-(3,5-di-tert-butyl-2-hydroxybenzylamino) acetic acid and the co-ligand L is 1,10-phenanthroline (phen, 1), dipyrido[3,2-d:2',3'-f]quinoxaline (dpq, 2) dipyrido [3,2-a:2',3'-c]phenazine (dppz, 3) have been isolated and characterized. Absorption and emission spectral studies and viscosity measurements indicated that 3 interacts with DNA more strongly than all of the other complexes through intercalation mode. Furthermore, cytotoxicity studies on the tested four cell line indicated that they can efficiently inhibit the cell proliferation in a time-dependent manner, and the Hoechst 33258 staining assays have also been employed in finding the extent of DNA damage.
学科主题	材料科学与物理化学
收录类别	SCI
语种	英语
WOS记录号	WOS:000327361400005
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/18098]
专题	兰州化学物理研究所_固体润滑国家重点实验室
作者单位	1.Henan Polytech Univ, Dept Chem & Phys, Jiaozuo 454000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China 3.Lanzhou Univ, Sch Life Sci, Inst Canc Biol & Drug Screening, Lanzhou 730000, Peoples R China
推荐引用方式 GB/T 7714	Jia L,Cai, Hong-xin,Xu, Jun,et al. Cytotoxic, cell apoptosis and DNA binding properties of some ternary Cu(II) complexes with a reduced Schiff base ligand and heterocyclic bases[J]. Inorganic Chemistry Communications,2013,35:16-18.
APA	Jia L.,Cai, Hong-xin.,Xu, Jun.,Zhou, Heng.,Wu, Wei-na.,...&Wang, Qin.(2013).Cytotoxic, cell apoptosis and DNA binding properties of some ternary Cu(II) complexes with a reduced Schiff base ligand and heterocyclic bases.Inorganic Chemistry Communications,35,16-18.
MLA	Jia L,et al."Cytotoxic, cell apoptosis and DNA binding properties of some ternary Cu(II) complexes with a reduced Schiff base ligand and heterocyclic bases".Inorganic Chemistry Communications 35(2013):16-18.