Hyperascyrones A-H, polyprenylated spirocyclic acylphloroglucinol derivatives from Hypericum ascyron Linn.

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Hyperascyrones A-H, polyprenylated spirocyclic acylphloroglucinol derivatives from Hypericum ascyron Linn.
	Zhu, Hucheng; Chen, Chunmei; Liu, Junjun; Sun, Bin; Wei, Guangzheng; Li, Yan; Zhang, Jinwen; Yao, Guangmin; Luo, Zengwei; Xue, Yongbo
刊名	PHYTOCHEMISTRY
	2015-07-01
卷号	115 页码:222-230
关键词	Hypericum ascyron Linn. Hypericaceae Polycyclic polyprenylated acylphloroglucinols Polyprenylated spirocyclic acylphloroglucinol derivatives Cytotoxic activities Anti-HIV-1 activities
英文摘要	Eight polyprenylated spirocyclic acylphloroglucinol derivatives (PSAPs), hyperascyrones A-H, were isolated from the aerial parts of Hypericum ascyron Linn., together with six known analogs. Their structures were established by spectroscopic analyses including HRESIMS, 1D and 2D NMR, and their absolute configurations were determined by electronic circular dichroism calculations (ECD, Gaussian 09). Structures of previously reported tomoeones C, D, G, and H were revised. Hyperascyrones A-H were evaluated for their cytotoxic and anti-HIV-1 activities, with hyperascyrones C and G exhibiting significant cytotoxicities against HL-60 cell lines with IC50 values of 4.22 and 8.36 mu M, respectively. In addition, the chemotaxonomic significance of these compounds was also discussed. (C) 2015 Elsevier Ltd. All rights reserved.
类目[WOS]	Biochemistry & Molecular Biology ; Plant Sciences
研究领域[WOS]	Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]	PHLOROGLUCINOL DERIVATIVES ; XANTHONES
收录类别	SCI
语种	英语
WOS记录号	WOS:000357237900022
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/24973]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式 GB/T 7714	Zhu, Hucheng,Chen, Chunmei,Liu, Junjun,et al. Hyperascyrones A-H, polyprenylated spirocyclic acylphloroglucinol derivatives from Hypericum ascyron Linn.[J]. PHYTOCHEMISTRY,2015,115:222-230.
APA	Zhu, Hucheng.,Chen, Chunmei.,Liu, Junjun.,Sun, Bin.,Wei, Guangzheng.,...&Zhang, Yonghui.(2015).Hyperascyrones A-H, polyprenylated spirocyclic acylphloroglucinol derivatives from Hypericum ascyron Linn..PHYTOCHEMISTRY,115,222-230.
MLA	Zhu, Hucheng,et al."Hyperascyrones A-H, polyprenylated spirocyclic acylphloroglucinol derivatives from Hypericum ascyron Linn.".PHYTOCHEMISTRY 115(2015):222-230.