Anti-inflammation Effects of Cordyceps sinensis Mycelium in Focal Cerebral Ischemic Injury Rats

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	Anti-inflammation Effects of Cordyceps sinensis Mycelium in Focal Cerebral Ischemic Injury Rats
	Liu, Zhenquan; Li, Pengtao; Zhao, Dan; Tang, Huiling; Guo, Jianyou
刊名	INFLAMMATION
	2011
卷号	34 期号:6 页码:639-644
关键词	CSM inflammation ischemia-reperfusion inflammatory cells inflammatory mediators
ISSN号	0360-3997
通讯作者	Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
产权排序	2
英文摘要	Brain ischemia-reperfusion (IR) triggers a complex series of biochemical events including inflammation. To test the neuroprotective efficacy of Cordyceps sinensis mycelium (CSM) in a rat model of focal cerebral IR, ischemic animals were treated with CSM. They were evaluated at 24 h after reperfusion for neurological deficit score. Furthermore, the mechanism of the anti-inflammatory potential of CSM in the regulation of nuclear factor kappaB, polymorphonuclear cells (PMN), interleukin-1 beta (IL-1 beta), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha), adhesion molecule (ICAM-1), and cyclooxygenase-2 (COX-2) was determined by ELISA and immunohistochemistry. CSM significantly inhibited IR-induced up-regulation of NF-kappaB activation and the brain production of IL-1 beta, TNF-alpha, iNOS, ICAM-1, and COX-2. Moreover, CSM suppressed infiltration of PMN. The study demonstrates the neuroprotective potential of CSM inhibition through anti-inflammation in a rat model of ischemia-reperfusion.
学科主题	Medical psychology
收录类别	SCI
项目简介	This work was supported by the Key New Drugs Innovation project from Ministry of Science and Technology (2009ZX09502-017), the project from Key Laboratory of Mental Health, Chinese Academy of Sciences, Young Scientist project from IPCAS (08CX043004), NNSF grant (30800301), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254).
原文出处	http://download.springer.com/static/pdf/894/art%253A10.1007%252Fs10753-010-9273-5.pdf?auth66=1422598012_5d9bb0759eb4c6687ee8916a40b0f65a&ext=.pdf
语种	英语
WOS记录号	WOS:000297198400016
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/14293]
专题	心理研究所_中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Liu, Zhenquan,Li, Pengtao,Zhao, Dan,et al. Anti-inflammation Effects of Cordyceps sinensis Mycelium in Focal Cerebral Ischemic Injury Rats[J]. INFLAMMATION,2011,34(6):639-644.
APA	Liu, Zhenquan,Li, Pengtao,Zhao, Dan,Tang, Huiling,&Guo, Jianyou.(2011).Anti-inflammation Effects of Cordyceps sinensis Mycelium in Focal Cerebral Ischemic Injury Rats.INFLAMMATION,34(6),639-644.
MLA	Liu, Zhenquan,et al."Anti-inflammation Effects of Cordyceps sinensis Mycelium in Focal Cerebral Ischemic Injury Rats".INFLAMMATION 34.6(2011):639-644.